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Claudia DOEL,Zhidong ZHANG,Lise MAZELET,Ryan WATERS,John BASHIRUDDIN
《农业科学与工程前沿(英文)》 2014年 第1卷 第3期 页码 250-257 doi: 10.15302/J-FASE-2014031
Review of hand, foot and mouth disease
Lan-Juan LI MD,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 139-146 doi: 10.1007/s11684-010-0033-6
关键词: hand foot and mouth disease epidemiology pathogenesis management surveillance
Progress on the research and development of human enterovirus 71 (EV71) vaccines
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 111-121 doi: 10.1007/s11684-012-0237-z
Enterovirus 71 (EV71) infections, which can cause severe complications, have become one of the serious public health issues in the Western Pacific region and China. To date, a number of pharmaceutical companies and institutes have initiated the research and development of EV71 vaccines as a countermeasure. As is the case with innovative vaccine development, there are several critical bottlenecks in EV71 vaccine development that must be overcome before the clinical trials, including the selection of vaccine strain, standardization of the procedure for quantifying neutralizing antibody (NTAb) and antigen, establishment and application of a reference standard and biological standards, development of animal models for the evaluation of protective efficacy, and identification of the target patient population. To tackle these technical obstacles, researchers in Mainland of China have conducted a series of studies concerning the screening of vaccine strains and the establishment of criteria, biological standards and detection methods, thereby advancing EV71 vaccine development. This review summarizes recent worldwide progress on the quality control and evaluation of EV71 vaccines.
关键词: enterovirus 71 (EV71) hand foot and mouth disease (HFMD) vaccine
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 249-261 doi: 10.1007/s11684-018-0622-3
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases. In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma. Controversial results from previous studies are discussed, and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver diseases, which might be caused by changes in natural killer T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer T cells and CD1d-expressing cells or bystander cells.
关键词: natural killer T cells hepatitis B virus and hepatitis C virus infection autoimmune liver diseases alcoholic liver disease nonalcoholic fatty liver disease hepatocellular carcinoma
Maliwan NACONSIE,Peng ZHANG
《农业科学与工程前沿(英文)》 2016年 第3卷 第4期 页码 285-294 doi: 10.15302/J-FASE-2016119
关键词: Manihot esculenta protein enhancement RNA interference transgenesis virus resistance
Mouth the mirror of lungs: where does the connection lie?
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 405-409 doi: 10.1007/s11684-016-0476-5
Periodontitis is the chronic destructive disease of the periodontium (Gums) caused by host bacterial interactions. The effect of such host bacterial interactions in oral cavity also evokes a systemic response. Numerous studies have found common mechanisms of destruction for periodontal diseases and other chronic diseases like diabetes mellitus, atherosclerosis, respiratory diseases, and adverse pregnancy outcomes. Oral colonization by respiratory pathogens appears to be a risk factor for development of respiratory diseases and oral interventions aimed at reducing oral bacterial count have resulted in reduced incidence of these reparatory illness. This reflects the importance of oral hygiene among patients with respiratory illness. This review highlights the association between periodontal diseases and respiratory diseases.
关键词: periodontitis respiratory diseases acute pneumonia COPD
Structural synthesis of ancient Chinese foot-operated silk-reeling mechanism
Kuohung HSIAO, Yuhsun CHEN, Hongsen YAN,
《机械工程前沿(英文)》 2010年 第5卷 第3期 页码 279-288 doi: 10.1007/s11465-010-0101-2
关键词: silk-reeling mechanism structure of mechanism reconstruction design history of machinery
Sufen ZHAO,Yuanyuan JIA,Weiwei ZHANG,Lili WANG,Yunfei MA,Kedao TENG
《农业科学与工程前沿(英文)》 2015年 第2卷 第4期 页码 318-326 doi: 10.15302/J-FASE-2015080
关键词: garlic infectious bursal disease virus (IBDV) antiviral effect IgM-bearing B lymphocyte
病毒性疾病对奶牛繁殖力的重要影响 Review
D. Claire Wathes, Chike F. Oguejiofor, Carole Thomas, Zhangrui Cheng
《工程(英文)》 2020年 第6卷 第1期 页码 26-33 doi: 10.1016/j.eng.2019.07.020
Planar jumping with stable landing through foot orientation design and ankle joint control
Qilong YUAN, I-Ming CHEN
《机械工程前沿(英文)》 2012年 第7卷 第2期 页码 100-108 doi: 10.1007/s11465-012-0318-3
This paper introduces a method to generate the planar jumping motion for biped robot. In this work, through determining the upper body posture trajectory in the flight phase, the foot landing posture is made to be flat while landing. Together with properly designing the trajectory for local center of gravity and the foot landing velocity, the soft landing trajectory is generated. A controller on the ankle joint is added to avoid significant impact with the ground and stabilize the robot after landing. Jumping motion with stable landing is achieved in a dynamic simulation environment based on this method.
关键词: biped jumping stable landing control jumping motion generation
Removal of virus aerosols by the combination of filtration and UV-C irradiation
《环境科学与工程前沿(英文)》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1627-y
● The removal of virus aerosols by filtration and UV-C irradiation was proposed.
关键词: Filtration system UV-C irradiation Virus aerosol Public health COVID-19
Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 260-267 doi: 10.15302/J-FASE-2016116
关键词: antiviral blood brain barrier chemokines and cytokines innate immunity rabies virus
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 480-489 doi: 10.1007/s11684-017-0594-8
Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
关键词: human immunodeficiency virus type I superinfection incidence immune response
Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus
Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO
《医学前沿(英文)》 2009年 第3卷 第2期 页码 158-163 doi: 10.1007/s11684-009-0042-5
关键词: tetracycline regulatory system adeno-associated virus basic fibroblast growth factor gene regulation
Advances in newly developing therapy for chronic hepatitis C virus infection
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 166-174 doi: 10.1007/s11684-014-0334-2
Chronic hepatitis C virus (HCV) infection afflicts a reported 170 million people worldwide and is often complicated by cirrhosis and hepatocellular carcinoma. Morbidity and mortality are decreased with the successful treatment of chronic HCV infection. Increased understanding of the HCV has allowed further development of new direct-acting antiviral (DAA) agents against the HCV and has also allowed the development of IFN-free oral treatment regimens. In late 2013 the first nucleotide polymerase inhibitor regimen with RBV alone for genotypes 2/3 and in combination with a 12-week regimen of PEG-IFN+RBV for genotypes 1, 4 was approved for use in the US. A number of promising new DAA regimens which are IFN-free are in phase 3 development and the first will likely be approved for use in the US in 2014. The currently approved regimens are discussed in detail and currently available data on future regimens are reviewed herein.
关键词: direct-acting antiviral (DAA) nucleotide polymerase inhibitors protease inhibitors
标题 作者 时间 类型 操作
Dynamics of foot-and-mouth disease virus replication in cells at different phases of the cell-division
Claudia DOEL,Zhidong ZHANG,Lise MAZELET,Ryan WATERS,John BASHIRUDDIN
期刊论文
Transgenic technologies in cassava for nutritional improvement and viral disease resistance: a key strategy
Maliwan NACONSIE,Peng ZHANG
期刊论文
Structural synthesis of ancient Chinese foot-operated silk-reeling mechanism
Kuohung HSIAO, Yuhsun CHEN, Hongsen YAN,
期刊论文
Planar jumping with stable landing through foot orientation design and ankle joint control
Qilong YUAN, I-Ming CHEN
期刊论文
Critical roles of chemokines and cytokines in antiviral innate immune responses during rabies virus infection
Ying HUANG, Clement Wesley GNANADURAI, Zhenfang FU
期刊论文
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
期刊论文
Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus
Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO
期刊论文